Document Type
Article
Publication Title
Medical Image Analysis
Abstract
The number of studies on deep learning for medical diagnosis is expanding, and these systems are often claimed to outperform clinicians. However, only a few systems have shown medical efficacy. From this perspective, we examine a wide range of deep learning algorithms for the assessment of glioblastoma - a common brain tumor in older adults that is lethal. Surgery, chemotherapy, and radiation are the standard treatments for glioblastoma patients. The methylation status of the MGMT promoter, a specific genetic sequence found in the tumor, affects chemotherapy's effectiveness. MGMT promoter methylation improves chemotherapy response and survival in several cancers. MGMT promoter methylation is determined by a tumor tissue biopsy, which is then genetically tested. This lengthy and invasive procedure increases the risk of infection and other complications. Thus, researchers have used deep learning models to examine the tumor from brain MRI scans to determine the MGMT promoter's methylation state. We employ deep learning models and one of the largest public MRI datasets of 585 participants to predict the methylation status of the MGMT promoter in glioblastoma tumors using MRI scans. We test these models using Grad-CAM, occlusion sensitivity, feature visualizations, and training loss landscapes. Our results show no correlation between these two, indicating that external cohort data should be used to verify these models’ performance to assure the accuracy and reliability of deep learning systems in cancer diagnosis.
DOI
10.1016/j.media.2023.102989
Publication Date
12-1-2023
Keywords
Deep learning, Glioblastoma, Interpretability, MGMT promoter, Radiogenomics
Recommended Citation
N. Saeed, M. Ridzuan, H. Alasmawi, I. Sobirov, and M. Yaqub, "MGMT promoter methylation status prediction using MRI scans? An extensive experimental evaluation of deep learning models", in Medical Image Analysis, vol 90 (102989), Dec 2023. doi:10.1016/j.media.2023.102989
Comments
Open Access, archived thanks to ScienceDirect
License: CC BY-NC-ND
Uploaded: May 30, 2024