DGM-DR: Domain Generalization with Mutual Information Regularized Diabetic Retinopathy Classification

Authors

Aleksandr Matsun, Mohamed Bin Zayed University of Artificial IntelligenceFollow
Dana O. Mohamed, Mohamed Bin Zayed University of Artificial IntelligenceFollow
Sharon Chokuwa, Mohamed Bin Zayed University of Artificial IntelligenceFollow
Muhammad Ridzuan, Mohamed Bin Zayed University of Artificial IntelligenceFollow
Mohammad Yaqub, Mohamed Bin Zayed University of Artificial IntelligenceFollow

Document Type

Conference Proceeding

Publication Title

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Abstract

The domain shift between training and testing data presents a significant challenge for training generalizable deep learning models. As a consequence, the performance of models trained with the independent and identically distributed (i.i.d) assumption deteriorates when deployed in the real world. This problem is exacerbated in the medical imaging context due to variations in data acquisition across clinical centers, medical apparatus, and patients. Domain generalization (DG) aims to address this problem by learning a model that generalizes well to any unseen target domain. Many domain generalization techniques were unsuccessful in learning domain-invariant representations due to the large domain shift. Furthermore, multiple tasks in medical imaging are not yet extensively studied in existing literature when it comes to DG point of view. In this paper, we introduce a DG method that re-establishes the model objective function as a maximization of mutual information with a large pretrained model to the medical imaging field. We re-visit the problem of DG in Diabetic Retinopathy (DR) classification to establish a clear benchmark with a correct model selection strategy and to achieve robust domain-invariant representation for an improved generalization. Moreover, we conduct extensive experiments on public datasets to show that our proposed method consistently outperforms the previous state-of-the-art by a margin of 5.25% in average accuracy and a lower standard deviation. Source code available at https://github.com/BioMedIA-MBZUAI/DGM-DR.

First Page

115

Last Page

125

DOI

10.1007/978-3-031-45857-6_12

Publication Date

10-14-2023

Keywords

Diabetic Retinopathy, Domain Generalization, Mutual Information Regularization

Comments

IR conditions: non-described

Recommended Citation

A. Matsun et al., "DGM-DR: Domain Generalization with Mutual Information Regularized Diabetic Retinopathy Classification," Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 14293 LNCS, pp. 115 - 125, Oct 2023.

The definitive version is available at https://doi.org/10.1007/978-3-031-45857-6_12

Additional Links

https://doi.org/10.1007/978-3-031-45857-6_12