MCMT-GAN: Multi-Task Coherent Modality Transferable GAN for 3D Brain Image Synthesis

Document Type

Article

Publication Title

IEEE Transactions on Image Processing

Abstract

The ability to synthesize multi-modality data is highly desirable for many computer-aided medical applications, e.g. clinical diagnosis and neuroscience research, since rich imaging cohorts offer diverse and complementary information unraveling human tissues. However, collecting acquisitions can be limited by adversary factors such as patient discomfort, expensive cost and scanner unavailability. In this paper, we propose a multi-task coherent modality transferable GAN (MCMT-GAN) to address this issue for brain MRI synthesis in an unsupervised manner. Through combining the bidirectional adversarial loss, cycle-consistency loss, domain adapted loss and manifold regularization in a volumetric space, MCMT-GAN is robust for multi-modality brain image synthesis with visually high fidelity. In addition, we complement discriminators collaboratively working with segmentors which ensure the usefulness of our results to segmentation task. Experiments evaluated on various cross-modality synthesis show that our method produces visually impressive results with substitutability for clinical post-processing and also exceeds the state-of-the-art methods.

First Page

8187

Last Page

8198

DOI

10.1109/TIP.2020.3011557

Publication Date

7-29-2020

Keywords

anatomical structure, brain MRI, GANs, multi-modality, Synthesis

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